Reaction Details |
| Report a problem with these data |
Target | Methionine aminopeptidase 1 |
---|
Ligand | BDBM50137353 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_105139 |
---|
Ki | 390000±n/a nM |
---|
Citation | Hu, X; Zhu, J; Srivathsan, S; Pei, D Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors. Bioorg Med Chem Lett14:77-9 (2003) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Methionine aminopeptidase 1 |
---|
Name: | Methionine aminopeptidase 1 |
Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
Type: | Enzyme |
Mol. Mass.: | 43220.79 |
Organism: | Homo sapiens (Human) |
Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
Residue: | 386 |
Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
|
|
|
BDBM50137353 |
---|
n/a |
---|
Name | BDBM50137353 |
Synonyms: | CHEMBL349154 | [((S)-2-Amino-4-methylsulfanyl-butyryl)-hydroxy-amino]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C7H14N2O4S |
Mol. Mass. | 222.262 |
SMILES | CSCC[C@H](N)C(=O)N(O)CC(O)=O |
Structure |
|