| Reaction Details |
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 | Report a problem with these data |
| Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Ligand | BDBM50571962 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116044 (CHEMBL4824985) |
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| IC50 | 2000±n/a nM |
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| Citation |  Akaki, T; Bessho, Y; Ito, T; Fujioka, S; Ubukata, M; Mori, G; Yamanaka, K; Orita, T; Doi, S; Iwanaga, T; Ikegashira, K; Hantani, Y; Nakanishi, I; Adachi, T Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem44:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
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| Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 46153.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15119 |
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| Residue: | 407 |
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| Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
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| BDBM50571962 |
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| n/a |
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| Name | BDBM50571962 |
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| Synonyms: | CHEMBL4862550 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2 |
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| Mol. Mass. | 222.2851 |
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| SMILES | Cc1cnc2[nH]c3c(cccc3c2c1)C1CC1 |
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| Structure | 
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