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Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
LigandBDBM50571960
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2116049 (CHEMBL4824990)
IC50 8400±n/a nM
Citation Akaki, T; Bessho, Y; Ito, T; Fujioka, S; Ubukata, M; Mori, G; Yamanaka, K; Orita, T; Doi, S; Iwanaga, T; Ikegashira, K; Hantani, Y; Nakanishi, I; Adachi, T Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem44:0 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Name:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Synonyms:PDHK3 | PDK3 | PDK3_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 3 (PDK3) | Pyruvate dehydrogenase kinase isoform 3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Type:Enzyme
Mol. Mass.:46944.89
Organism:Homo sapiens (Human)
Description:Q15120
Residue:406
Sequence:
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT
MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN
DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH
PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH
LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL
FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA
LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
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  Blast E-value cutoff:
BDBM50571960
n/a
NameBDBM50571960
Synonyms:CHEMBL4848983
TypeSmall organic molecule
Emp. Form.C11H14N2O
Mol. Mass.190.2417
SMILESCNc1cccc2c1NC(=O)C2(C)C
Structure
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