| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase family 1 member A3 |
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| Ligand | BDBM50572095 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116258 (CHEMBL4825199) |
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| IC50 | 590±n/a nM |
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| Citation |  Ma, Z; Jiang, L; Li, B; Liang, D; Feng, Y; Liu, L; Jiang, C Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Med Chem46:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase family 1 member A3 |
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| Name: | Aldehyde dehydrogenase family 1 member A3 |
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| Synonyms: | AL1A3_HUMAN | ALDH1A3 | ALDH6 | Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56110.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109700 |
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| Residue: | 512 |
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| Sequence: | MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQI
CEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETM
DTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPW
NFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTV
GAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVE
CAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQK
QFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPIL
KFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGF
KMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
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| BDBM50572095 |
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| n/a |
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| Name | BDBM50572095 |
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| Synonyms: | CHEMBL4862473 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25F3N4O |
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| Mol. Mass. | 442.4767 |
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| SMILES | FC(F)(F)c1cccc(Cn2c(CN3CCN(CC3)C(=O)C3CC3)nc3ccccc23)c1 |
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| Structure | 
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