Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM50137621

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_62750

0.400000±n/a nM

Citation

Mach, RH; Huang, Y; Freeman, RA; Wu, L; Vangveravong, S; Luedtke, RR Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands. Bioorg Med Chem Lett14:195-202 (2003) [PubMed]

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3

Type:

Protein

Mol. Mass.:

49540.58

Organism:

Rattus norvegicus (Rat)

Description:

P19020

Residue:

446

Sequence:

MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC

BDBM50137621

n/a

Name

BDBM50137621

Synonyms:

4-Bromo-1-methoxy-naphthalene-2-carboxylic acid (1-adamantan-2-yl-pyrrolidin-3-yl)-amide | CHEMBL62638

Type

Small organic molecule

Emp. Form.

C26H31BrN2O2

Mol. Mass.

483.441

SMILES

COc1c(cc(Br)c2ccccc12)C(=O)NC1CCN(C1)C1C2CC3CC(C2)CC1C3 |TLB:30:29:27:24.23.25,THB:19:21:27:24.23.25,30:24:27:21.29.28,25:26:21:24.23.30,25:24:21:26.27.28,(.47,2.25,;1.82,1.5,;1.82,-.03,;3.16,-.8,;3.17,-2.33,;1.83,-3.11,;1.83,-4.64,;.5,-2.34,;-.85,-3.12,;-2.18,-2.35,;-2.18,-.81,;-.85,-.05,;.5,-.81,;4.49,-.02,;4.49,1.51,;5.83,-.77,;7.16,-.01,;7.31,1.52,;8.81,1.85,;9.6,.53,;8.57,-.63,;11.12,.37,;11.75,-1.04,;12.58,.32,;14.74,1.09,;15.98,.44,;14.17,.06,;13.28,-1.19,;13.54,1.45,;12.01,1.62,;13.47,2.41,)|

Structure