| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 1 |
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| Ligand | BDBM50572901 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2118551 (CHEMBL4827617) |
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| IC50 | 2614±n/a nM |
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| Citation |  Eduful, BJ; O'Byrne, SN; Temme, L; Asquith, CRM; Liang, Y; Picado, A; Pilotte, JR; Hossain, MA; Wells, CI; Zuercher, WJ; Catta-Preta, CMC; Zonzini Ramos, P; Santiago, AS; Couņago, RM; Langendorf, CG; Nay, K; Oakhill, JS; Pulliam, TL; Lin, C; Awad, D; Willson, TM; Frigo, DE; Scott, JW; Drewry, DH Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem64:10849-10877 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 1 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 1 |
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| Synonyms: | CAMKK1 | CAMKKA | CaM-kinase kinase alpha | KKCC1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55727.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774623 |
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| Residue: | 505 |
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| Sequence: | MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
LVKEGFGEGGKSPELPGVQEDEAAS
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| BDBM50572901 |
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| n/a |
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| Name | BDBM50572901 |
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| Synonyms: | CHEMBL4849143 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N2O2 |
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| Mol. Mass. | 394.4651 |
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| SMILES | OC(=O)c1ccc(cc1C1CCCC1)-c1ncnc2ccc(cc12)-c1ccccc1 |
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| Structure | 
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