| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 8 |
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| Ligand | BDBM50163795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119599 (CHEMBL4828665) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Hatcher, JM; Vatsan, PS; Wang, E; Jiang, J; Gray, NS Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett12:1689-1693 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 8 |
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| Name: | Cyclin-dependent kinase 8 |
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| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 53300.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49336 |
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| Residue: | 464 |
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| Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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| BDBM50163795 |
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| n/a |
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| Name | BDBM50163795 |
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| Synonyms: | CHEMBL3798382 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClN6O |
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| Mol. Mass. | 410.9 |
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| SMILES | Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CCNC2=O)CC1 |
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| Structure | 
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