BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 44 hits Enz. Inhib. hit(s) with all data for entry = 50014191   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-C


(Homo sapiens (Human))
BDBM50573483
PNG
(CHEMBL4877883)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]nc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573482
PNG
(CHEMBL4858092)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]cc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573487
PNG
(CHEMBL4850566)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CC1)NC(=O)NC2=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573483
PNG
(CHEMBL4877883)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]nc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573471
PNG
(CHEMBL4856360)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50573483
PNG
(CHEMBL4877883)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]nc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50191357
PNG
(CHEMBL3903492)
Show SMILES Cc1n[nH]c2ncc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens (Human))
BDBM50573488
PNG
(CHEMBL4849842)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573488
PNG
(CHEMBL4849842)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573487
PNG
(CHEMBL4850566)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CC1)NC(=O)NC2=O
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573473
PNG
(CHEMBL4851074)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]cnc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50163795
PNG
(CHEMBL3798382)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CCNC2=O)CC1
Show InChI InChI=1S/C21H23ClN6O/c1-27-16-3-2-13(10-14(16)11-26-27)15-12-25-19(23)17(22)18(15)28-8-5-21(6-9-28)4-7-24-20(21)29/h2-3,10-12H,4-9H2,1H3,(H2,23,25)(H,24,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens (Human))
BDBM50573480
PNG
(CHEMBL4869328)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2[nH]cnc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573475
PNG
(CHEMBL4872393)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2scnc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573489
PNG
(CHEMBL4878356)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573489
PNG
(CHEMBL4878356)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573490
PNG
(CHEMBL4862777)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CNC(=O)O2)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573490
PNG
(CHEMBL4862777)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CNC(=O)O2)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573471
PNG
(CHEMBL4856360)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573476
PNG
(CHEMBL4874290)
Show SMILES Cn1cnc2ccc(cc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573482
PNG
(CHEMBL4858092)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]cc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573473
PNG
(CHEMBL4851074)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]cnc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573476
PNG
(CHEMBL4874290)
Show SMILES Cn1cnc2ccc(cc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573475
PNG
(CHEMBL4872393)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2scnc2c1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573480
PNG
(CHEMBL4869328)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2[nH]cnc2c1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573477
PNG
(CHEMBL4868667)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2ncsc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573486
PNG
(CHEMBL4845941)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)C1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 29n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573478
PNG
(CHEMBL4869240)
Show SMILES Cn1cnc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 32n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 8


(Homo sapiens (Human))
BDBM50573471
PNG
(CHEMBL4856360)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 46n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot ...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573478
PNG
(CHEMBL4869240)
Show SMILES Cn1cnc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573486
PNG
(CHEMBL4845941)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CCNC2=O)C1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 55n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573481
PNG
(CHEMBL4848729)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccn2ccnc2c1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 68n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573481
PNG
(CHEMBL4848729)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccn2ccnc2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 76n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573477
PNG
(CHEMBL4868667)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2ncsc2c1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase 16


(Homo sapiens (Human))
BDBM50573483
PNG
(CHEMBL4877883)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]nc(Cl)c2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 107n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human wild type partial length STK16 (G11 to I305) expressed in bacterial expression system by Kinomescan method


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573472
PNG
(CHEMBL4872958)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ncc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 178n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573474
PNG
(CHEMBL4874173)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2sccc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 206n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573472
PNG
(CHEMBL4872958)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ncc2c1N1CCC2(CCNC2=O)CC1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 214n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573479
PNG
(CHEMBL4854223)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2ncnn2c1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 274n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573485
PNG
(CHEMBL4864356)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CC2(C1)CCNC2=O
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 426n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573485
PNG
(CHEMBL4864356)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CC2(C1)CCNC2=O
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 538n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573484
PNG
(CHEMBL4856609)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CC2(C1)CNC(=O)C2
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 698n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens (Human))
BDBM50573484
PNG
(CHEMBL4856609)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CC2(C1)CNC(=O)C2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 916n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair
Cyclin-C/Cyclin-dependent kinase 19


(Homo sapiens (Human))
BDBM50573479
PNG
(CHEMBL4854223)
Show SMILES O=C1NCCC11CCN(CC1)c1c(cnc2[nH]ccc12)-c1ccc2ncnn2c1
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.02E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00300
BindingDB Entry DOI: 10.7270/Q29W0K80
More data for this
Ligand-Target Pair