Reaction Details |
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Target | Caspase-1 |
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Ligand | BDBM50139694 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_46518 (CHEMBL659312) |
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IC50 | 174000±n/a nM |
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Citation | Harter, WG; Albrect, H; Brady, K; Caprathe, B; Dunbar, J; Gilmore, J; Hays, S; Kostlan, CR; Lunney, B; Walker, N The design and synthesis of sulfonamides as caspase-1 inhibitors. Bioorg Med Chem Lett14:809-12 (2004) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-1 |
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Name: | Caspase-1 |
Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
Type: | Enzyme |
Mol. Mass.: | 45154.13 |
Organism: | Homo sapiens (Human) |
Description: | P29466 |
Residue: | 404 |
Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
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BDBM50139694 |
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n/a |
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Name | BDBM50139694 |
Synonyms: | 3-Benzyloxycarbonylamino-5-(naphthalene-1-sulfonylamino)-4-oxo-pentanoic acid | CHEMBL168724 |
Type | Small organic molecule |
Emp. Form. | C23H22N2O7S |
Mol. Mass. | 470.495 |
SMILES | OC(=O)CC(NC(=O)OCc1ccccc1)C(=O)CNS(=O)(=O)c1cccc2ccccc12 |
Structure |
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