| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
|---|
| Ligand | BDBM50139763 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_72502 (CHEMBL683936) |
|---|
| IC50 | 2±n/a nM |
|---|
| Citation |  Shi, ZD; Lee, K; Wei, CQ; Roberts, LR; Worthy, KM; Fisher, RJ; Burke, TR Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity. J Med Chem47:788-91 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Growth factor receptor-bound protein 2 |
|---|
| Name: | Growth factor receptor-bound protein 2 |
|---|
| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25205.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P62993 |
|---|
| Residue: | 217 |
|---|
| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
|
|
|
|---|
| BDBM50139763 |
|---|
| n/a |
|---|
| Name | BDBM50139763 |
|---|
| Synonyms: | CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid | [(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-10-((1S,4S)-4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H47N4O9P |
|---|
| Mol. Mass. | 746.7856 |
|---|
| SMILES | NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1 |t:24| |
|---|
| Structure | 
|
|---|
Search and Browse
