| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-9 |
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| Ligand | BDBM50573703 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2120229 (CHEMBL4829376) |
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| IC50 | 66±n/a nM |
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| Citation |  Lee, MJ; Bhattarai, D; Jang, H; Baek, A; Yeo, IJ; Lee, S; Miller, Z; Lee, S; Hong, JT; Kim, DE; Lee, W; Kim, KB Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease. J Med Chem64:10934-10950 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-9 |
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| Name: | Proteasome subunit beta type-9 |
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| Synonyms: | LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 23256.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 219 |
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| Sequence: | MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
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| BDBM50573703 |
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| n/a |
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| Name | BDBM50573703 |
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| Synonyms: | CHEMBL4870740 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H42N4O7 |
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| Mol. Mass. | 522.6343 |
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| SMILES | [H][C@@]12CCCN1C(=O)CNC(=O)CCCCCCOC[C@H](NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| |
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| Structure | 
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