| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
|---|
| Ligand | BDBM50573717 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2120433 (CHEMBL4829580) |
|---|
| IC50 | 6.0±n/a nM |
|---|
| Citation |  Yang, Y; Yu, D; Zhu, X; Du, G; Wang, W; Zou, F; Wang, H; Zhang, R; Ye, L; Tian, J Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors. Eur J Med Chem224:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Synaptic vesicular amine transporter |
|---|
| Name: | Synaptic vesicular amine transporter |
|---|
| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55689.58 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q01827 |
|---|
| Residue: | 515 |
|---|
| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
|
|
|
|---|
| BDBM50573717 |
|---|
| n/a |
|---|
| Name | BDBM50573717 |
|---|
| Synonyms: | CHEMBL4854730 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H28F3NO3 |
|---|
| Mol. Mass. | 387.4364 |
|---|
| SMILES | COc1cc2C3CC(O)C(CC(C)C)CN3CCc2cc1OCC(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
