| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2b |
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| Ligand | BDBM50135752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87717 (CHEMBL857174) |
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| IC50 | 100±n/a nM |
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| Citation |  Mai, A; Massa, S; Cerbara, I; Valente, S; Ragno, R; Bottoni, P; Scatena, R; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J Med Chem47:1098-109 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2b |
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| Name: | Histone deacetylase 2b |
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| Synonyms: | Histone deacetylase HD2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30785.07 |
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| Organism: | Zea mays |
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| Description: | ChEMBL_87549 |
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| Residue: | 286 |
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| Sequence: | MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVE
KHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQN
NEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEM
SEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSE
QSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
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| BDBM50135752 |
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| n/a |
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| Name | BDBM50135752 |
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| Synonyms: | (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide | (E)-N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | CHEMBL12760 | N-Hydroxy-3-((E)-1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide | N-Hydroxy-3-(1-methyl-4-phenylacetyl-1H-pyrrol-2-yl)-acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O3 |
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| Mol. Mass. | 284.3098 |
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| SMILES | Cn1cc(cc1C=CC(=O)NO)C(=O)Cc1ccccc1 |w:7.8| |
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| Structure | 
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