| Reaction Details |
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 | Report a problem with these data |
| Target | Pannexin-1 |
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| Ligand | BDBM50574565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2122674 (CHEMBL4831907) |
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| IC50 | 4900±n/a nM |
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| Citation |  Crocetti, L; Guerrini, G; Puglioli, S; Giovannoni, MP; Di Cesare Mannelli, L; Lucarini, E; Ghelardini, C; Wang, J; Dahl, G Design and synthesis of the first indole-based blockers of Panx-1 channel. Eur J Med Chem223:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pannexin-1 |
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| Name: | Pannexin-1 |
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| Synonyms: | PANX1_MOUSE | Pannexin-1 | Panx1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48168.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120484 |
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| Residue: | 426 |
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| Sequence: | MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILL
YLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQ
SLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLS
DEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQ
KTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGI
DPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQR
LLNPSC
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| BDBM50574565 |
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| n/a |
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| Name | BDBM50574565 |
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| Synonyms: | CHEMBL4858078 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12N2O6 |
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| Mol. Mass. | 340.287 |
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| SMILES | OC(=O)c1cc2cc(ccc2n1Cc1ccc(cc1)C(O)=O)[N+]([O-])=O |
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| Structure | 
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