| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pannexin-1 |
|---|
| Ligand | BDBM50247012 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2122674 (CHEMBL4831907) |
|---|
| IC50 | 10000±n/a nM |
|---|
| Citation |  Crocetti, L; Guerrini, G; Puglioli, S; Giovannoni, MP; Di Cesare Mannelli, L; Lucarini, E; Ghelardini, C; Wang, J; Dahl, G Design and synthesis of the first indole-based blockers of Panx-1 channel. Eur J Med Chem223:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pannexin-1 |
|---|
| Name: | Pannexin-1 |
|---|
| Synonyms: | PANX1_MOUSE | Pannexin-1 | Panx1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48168.73 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_120484 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI
GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLPLWLHKFFPYILLLFAILL
YLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQ
SLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFVVILLACIYLSYYFSLSSLS
DEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLSLINLIVYALLIPVVVYTFFIPFRQ
KTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGI
DPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQGSQRVEFKDLDLSSEAAANNGEKNSRQR
LLNPSC
|
|
|
|---|
| BDBM50247012 |
|---|
| n/a |
|---|
| Name | BDBM50247012 |
|---|
| Synonyms: | 3beta-O-Succinyl-18-beta-glycyrrhetinic acid | Carbenoxolone | US11660306, Example Carbeanoxolone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H50O7 |
|---|
| Mol. Mass. | 570.7566 |
|---|
| SMILES | CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O |r,t:18| |
|---|
| Structure | 
|
|---|
Search and Browse
