| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2b |
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| Ligand | BDBM50140882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87886 (CHEMBL698804) |
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| IC50 | 50±n/a nM |
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| Citation |  Ragno, R; Mai, A; Massa, S; Cerbara, I; Valente, S; Bottoni, P; Scatena, R; Jesacher, F; Loidl, P; Brosch, G 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem47:1351-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2b |
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| Name: | Histone deacetylase 2b |
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| Synonyms: | Histone deacetylase HD2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30785.07 |
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| Organism: | Zea mays |
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| Description: | ChEMBL_87549 |
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| Residue: | 286 |
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| Sequence: | MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVE
KHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQN
NEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEM
SEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSE
QSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
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| BDBM50140882 |
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| n/a |
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| Name | BDBM50140882 |
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| Synonyms: | (E)-3-(5-Benzoyl-1-methyl-1H-pyrrol-3-yl)-N-hydroxy-acrylamide | 3-(5-benzoyl-1-methyl-1H-pyrrol-3-yl)-N-hydroxyacrylamide | CHEMBL29814 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2O3 |
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| Mol. Mass. | 270.2833 |
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| SMILES | Cn1cc(\C=C\C(=O)NO)cc1C(=O)c1ccccc1 |
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| Structure | 
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