| Reaction Details |
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 | Report a problem with these data |
| Target | Type-2 angiotensin II receptor |
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| Ligand | BDBM50141048 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35278 (CHEMBL648317) |
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| Ki | 8±n/a nM |
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| Citation |  Wan, Y; Wallinder, C; Johansson, B; Holm, M; Mahalingam, AK; Wu, X; Botros, M; Karlén, A; Pettersson, A; Nyberg, F; Fändriks, L; Hallberg, A; Alterman, M First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo. J Med Chem47:1536-46 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-2 angiotensin II receptor |
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| Name: | Type-2 angiotensin II receptor |
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| Synonyms: | AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41201.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Angiotensin II, central 0 0::P50052 |
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| Residue: | 363 |
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| Sequence: | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
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| BDBM50141048 |
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| n/a |
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| Name | BDBM50141048 |
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| Synonyms: | CHEMBL287829 | N-Butyloxycarbonyl-5-isobutyl-3-(4-{6-[N-(thiophene-2-carbonyl)ethylamino]-4-oxo-2-propyl-4H-quinazolin-3-ylmethyl}phenyl)-thiophene-2-sulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C38H44N4O6S3 |
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| Mol. Mass. | 748.974 |
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| SMILES | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(cc3c2=O)N(CC)C(=O)c2cccs2)cc1 |
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| Structure | 
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