| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 3 |
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| Ligand | BDBM50141410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_104056 |
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| IC50 | >1000±n/a nM |
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| Citation |  Wityak, J; Hobbs, FW; Gardner, DS; Santella, JB; Petraitis, JJ; Sun, JH; Favata, MF; Daulerio, AJ; Horiuchi, KY; Copeland, RA; Scherle, PA; Jaffe, BD; Trzaskos, JM; Magolda, RL; Trainor, GL; Duncia, JV Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors. Bioorg Med Chem Lett14:1483-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 3 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 3 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 3 | MAP kinase kinase 3 | MAP2K3 | MAPK/ERK kinase 3 | MAPK/ERK kinase 3 (MEK3) | MAPKK 3 | MEK3 | MKK3 | MP2K3_HUMAN | PRKMK3 | SKK2 |
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| Type: | Protein |
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| Mol. Mass.: | 39321.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 347 |
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| Sequence: | MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
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| BDBM50141410 |
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| n/a |
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| Name | BDBM50141410 |
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| Synonyms: | (Z)-3-Amino-3-(2-amino-phenylsulfanyl)-2-[3-(hydroxy-pyridin-4-yl-methyl)-phenyl]-acrylonitrile | CHEMBL37493 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18N4OS |
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| Mol. Mass. | 374.459 |
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| SMILES | Nc1ccccc1SC(=N)C(C#N)c1cccc(c1)C(O)c1ccncc1 |
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| Structure | 
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