| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50141605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_196596 |
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| IC50 | 128±n/a nM |
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| Citation |  Michellys, PY; D'Arrigo, J; Grese, TA; Karanewsky, DS; Leibowitz, MD; Mais, DA; Mapes, CM; Reifel-Miller, A; Rungta, D; Boehm, MF Design, synthesis and structure-activity relationship of novel RXR-selective modulators. Bioorg Med Chem Lett14:1593-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50820.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456363 |
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| Residue: | 462 |
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| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM50141605 |
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| n/a |
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| Name | BDBM50141605 |
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| Synonyms: | (E)-3-[7-(3,5-Diisopropyl-2-propoxy-phenyl)-benzofuran-2-yl]-but-2-enoic acid | CHEMBL41675 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32O4 |
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| Mol. Mass. | 420.5406 |
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| SMILES | CCCOc1c(cc(cc1-c1cccc2cc(oc12)C(\C)=C\C(O)=O)C(C)C)C(C)C |
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| Structure | 
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