| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 2 |
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| Ligand | BDBM50575378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2125154 (CHEMBL4834499) |
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| IC50 | 400±n/a nM |
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| Citation |  Lee, S; Cil, O; Diez-Cecilia, E; Anderson, MO; Verkman, AS Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem61:3209-3217 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 2 |
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| Name: | Urea transporter 2 |
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| Synonyms: | Slc14a2 | UT2_RAT | Urea transporter 2 | Urea transporter A1 (UT-A1) | Ut2 |
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| Type: | Protein |
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| Mol. Mass.: | 101906.19 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 929 |
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| Sequence: | MSDHPLKEMSDNNRSPPLPEPLSSRYKLYESELSSPTWPSSSQDTHPALPLLEMPEEKDL
RSSDEDSHIVKIEKPNERSKRRESELPRRASAGRGAFSLFQAVSYLTGDMKECKNWLKDK
PLVLQFLDWVLRGAAQVMFVNNPLSGLIIFIGLLIQNPWWTIAGALGTVVSTLAALALSQ
DRSAIASGLHGYNGMLVGLLVAVFSEKLDYYWWLLFPVTFASMACPVISSALSTVFAKWD
LPVFTLPFNIALTLYLAATGHYNLFFPTTLVKPASSAPNITWSEIEMPLLLQTIPVGVGQ
VYGCDNPWTGGVILVALFISSPLICLHAAIGSIVGLLAALTVATPFETIYTGLWSYNCVL
SCVAIGGMFYVLTWQTHLLALVCALFCAYTGAALSNMMAVVGVPPGTWAFCLSTLTFLLL
TSNNPGIHKLPLSKVTYPEANRIYFLTAKRSDEQKPPNGGGGEQSHGGGQRKAEEGSETV
FPRRKSVFHIEWSSIRRRSKVFGKSEHQERQTKEPLPYLYRKPTVELLDLNTMEESSEIK
VETNTTRTTWIQSSMIAGGKRVSKALSYITGEMKECGEGLKDKSPVFQFLDWVLRGTSQV
MFVNNPLSGILIVLGLFVQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGLHGYNGVLV
GLLMAVFSDKGNYYWWLLLPVIVMSMTCPILSSALSTVFSKWDLPVFTLPFNIAVTLYLA
ATGHYNLFFPTKLLQPAVTTPNITWSDVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLVAL
FVSSPLICLHAAIGSTIGMLAALSIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTH
LLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPGIYKLPLSKVTY
PEANRIYFLSQEKNRRASMITKYQAYDVS
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| BDBM50575378 |
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| n/a |
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| Name | BDBM50575378 |
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| Synonyms: | CHEMBL4849241 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25N5O4S |
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| Mol. Mass. | 503.573 |
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| SMILES | CCCc1nnc2c(Oc3ccc(NS(=O)(=O)c4cc(C)ccc4OC)cc3)nc3ccccc3n12 |
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| Structure | 
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