| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 |
|---|
| Ligand | BDBM50304072 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2126181 (CHEMBL4835526) |
|---|
| Kd | 3200000±n/a nM |
|---|
| Citation |  Pallesen, JS; Narayanan, D; Tran, KT; Solbak, SMØ; Marseglia, G; Sørensen, LME; Høj, LJ; Munafò, F; Carmona, RMC; Garcia, AD; Desu, HL; Brambilla, R; Johansen, TN; Popowicz, GM; Sattler, M; Gajhede, M; Bach, A Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. J Med Chem64:4623-4661 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kelch-like ECH-associated protein 1 |
|---|
| Name: | Kelch-like ECH-associated protein 1 |
|---|
| Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69664.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107924 |
|---|
| Residue: | 624 |
|---|
| Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
|
|
|
|---|
| BDBM50304072 |
|---|
| n/a |
|---|
| Name | BDBM50304072 |
|---|
| Synonyms: | 3-PHENYLPROPIONIC ACID3-Phenyl-propionic acid | 3-phenylpropanoic acid | CHEMBL851 | HYDROCINNAMIC ACID | Phenyl propionic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H10O2 |
|---|
| Mol. Mass. | 150.1745 |
|---|
| SMILES | OC(=O)CCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
