| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
|---|
| Ligand | BDBM50576669 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2127676 (CHEMBL4837021) |
|---|
| IC50 | 5.6±n/a nM |
|---|
| Citation |  Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH 1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties. Bioorg Med Chem Lett47:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Eukaryotic initiation factor 4A-I |
|---|
| Name: | Eukaryotic initiation factor 4A-I |
|---|
| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 46146.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_864983 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
|
|
|
|---|
| BDBM50576669 |
|---|
| n/a |
|---|
| Name | BDBM50576669 |
|---|
| Synonyms: | CHEMBL4855528 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23N3O3 |
|---|
| Mol. Mass. | 413.4684 |
|---|
| SMILES | COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
