| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-I |
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| Ligand | BDBM50576672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2127676 (CHEMBL4837021) |
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| IC50 | 2.3±n/a nM |
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| Citation |  Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH 1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties. Bioorg Med Chem Lett47:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-I |
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| Name: | Eukaryotic initiation factor 4A-I |
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| Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46146.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_864983 |
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| Residue: | 406 |
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| Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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| BDBM50576672 |
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| n/a |
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| Name | BDBM50576672 |
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| Synonyms: | CHEMBL4857096 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29BrN2O5 |
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| Mol. Mass. | 553.444 |
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| SMILES | COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| |
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| Structure | 
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