| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Ligand | BDBM50576941 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2128506 (CHEMBL4837935) |
|---|
| IC50 | 6.0±n/a nM |
|---|
| Citation |  Stanford, SM; Diaz, MA; Ardecky, RJ; Zou, J; Roosild, T; Holmes, ZJ; Nguyen, TP; Hedrick, MP; Rodiles, S; Guan, A; Grotegut, S; Santelli, E; Chung, TDY; Jackson, MR; Bottini, N; Pinkerton, AB Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase. J Med Chem64:5645-5653 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Name: | Low molecular weight phosphotyrosine protein phosphatase |
|---|
| Synonyms: | 3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 18042.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24666 |
|---|
| Residue: | 158 |
|---|
| Sequence: | MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
|
|
|
|---|
| BDBM50576941 |
|---|
| n/a |
|---|
| Name | BDBM50576941 |
|---|
| Synonyms: | CHEMBL4875137 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14Cl2N6 |
|---|
| Mol. Mass. | 385.25 |
|---|
| SMILES | Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cncc3Cl)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
