Reaction Details |
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Target | Alpha-1D adrenergic receptor |
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Ligand | BDBM50143687 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_32721 (CHEMBL645993) |
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Ki | 0.2±n/a nM |
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Citation | Leonardi, A; Barlocco, D; Montesano, F; Cignarella, G; Motta, G; Testa, R; Poggesi, E; Seeber, M; De Benedetti, PG; Fanelli, F Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor. J Med Chem47:1900-18 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1D adrenergic receptor |
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Name: | Alpha-1D adrenergic receptor |
Synonyms: | ADA1D_RAT | Adra1a | Adra1d | Alpha adrenergic receptor 1A and 1D | Alpha-1D adrenergic receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 |
Type: | Protein |
Mol. Mass.: | 59375.97 |
Organism: | Rattus norvegicus (Rat) |
Description: | P23944 |
Residue: | 561 |
Sequence: | MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDN
QSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRH
LQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILS
LCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFC
GITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRI
HCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF
VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR
RLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKP
ASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGA
EAVICQAYEPGDYSNLRETDI
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BDBM50143687 |
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n/a |
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Name | BDBM50143687 |
Synonyms: | 4-Chloro-2-{4-[2-(7,9-dioxo-8-aza-spiro[4.5]dec-8-yl)-ethyl]-piperazin-1-yl}-benzonitrile | CHEMBL57868 |
Type | Small organic molecule |
Emp. Form. | C22H27ClN4O2 |
Mol. Mass. | 414.928 |
SMILES | Clc1ccc(C#N)c(c1)N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 |
Structure |
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