| Reaction Details |
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 | Report a problem with these data |
| Target | Glyceraldehyde-3-phosphate dehydrogenase |
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| Ligand | BDBM50144452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72894 (CHEMBL684061) |
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| IC50 | 100±n/a nM |
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| Citation |  Leitão, A; Andricopulo, AD; Oliva, G; Pupo, MT; de Marchi, AA; Vieira, PC; da Silva, MF; Ferreira, VF; de Souza, MC; Sá, MM; Moraes, VR; Montanari, CA Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase. Bioorg Med Chem Lett14:2199-204 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glyceraldehyde-3-phosphate dehydrogenase |
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| Name: | Glyceraldehyde-3-phosphate dehydrogenase |
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| Synonyms: | G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36060.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1511315 |
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| Residue: | 335 |
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| Sequence: | MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV
KAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVI
ISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHA
ITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANV
SVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAG
IALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
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| BDBM50144452 |
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| n/a |
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| Name | BDBM50144452 |
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| Synonyms: | Adenosine analogue | CHEMBL3559427 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H42N8O15P2 |
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| Mol. Mass. | 936.7536 |
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| SMILES | COc1cccc(c1)C(=O)NC1C(O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H](C(O)C2O)[n+]2ccc(cc2)C(N)=O)O[C@H]1n1cnc2c(NCc3cccc4ccccc34)ncnc12 |
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| Structure | 
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