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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 9 | ||
| Ligand | BDBM50578351 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2132759 (CHEMBL4842274) | ||
| IC50 | 13±n/a nM | ||
| Citation |  Nagy, MA; Hilgraf, R; Mortensen, DS; Elsner, J; Norris, S; Tikhe, J; Yoon, W; Paisner, D; Delgado, M; Erdman, P; Haelewyn, J; Khambatta, G; Xu, L; Romanow, WJ; Condroski, K; Bahmanyar, S; McCarrick, M; Benish, B; Blease, K; LeBrun, L; Moghaddam, MF; Apuy, J; Canan, SS; Bennett, BL; Satoh, Y Discovery of the c-Jun N-Terminal Kinase Inhibitor J Med Chem64:18193-18208 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 9 | |||
| Name: | Mitogen-activated protein kinase 9 | ||
| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48131.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
| Residue: | 424 | ||
| Sequence: |
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| BDBM50578351 | |||
| n/a | |||
| Name | BDBM50578351 | ||
| Synonyms: | CHEMBL4862452 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H23N5O2 | ||
| Mol. Mass. | 317.3861 | ||
| SMILES | NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC(C1)C2 |r,wU:8.7,wD:11.11,(35.38,-6.44,;34.05,-5.67,;34.04,-4.13,;32.72,-6.45,;31.38,-5.69,;30.05,-6.46,;30.05,-8,;28.72,-8.77,;27.38,-8,;26.06,-8.77,;24.72,-7.99,;24.73,-6.45,;23.4,-5.67,;26.07,-5.69,;27.39,-6.46,;31.38,-8.77,;32.73,-7.99,;34.06,-8.76,;34.07,-10.3,;32.99,-11.38,;34.08,-12.47,;35.17,-11.38,;33.65,-11.15,)| | ||
| Structure | 
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