| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-1 |
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| Ligand | BDBM50145661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_46513 |
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| IC50 | 27±n/a nM |
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| Citation |  Linton, SD; Aja, T; Allegrini, PR; Deckwerth, TL; Diaz, JL; Hengerer, B; Herrmann, J; Jahangiri, KG; Kallen, J; Karanewsky, DS; Meduna, SP; Nalley, K; Robinson, ED; Roggo, S; Rovelli, G; Sauter, A; Sayers, RO; Schmitz, A; Smidt, R; Ternansky, RJ; Tomaselli, KJ; Ullman, BR; Wiessner, C; Wu, JC Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke. Bioorg Med Chem Lett14:2685-91 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-1 |
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| Name: | Caspase-1 |
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| Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45636.44 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_651546 |
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| Residue: | 402 |
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| Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
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| BDBM50145661 |
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| n/a |
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| Name | BDBM50145661 |
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| Synonyms: | (S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl)-amino]-pentanoylamino}-4-oxo-butyric acid | CHEMBL90307 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N3O6 |
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| Mol. Mass. | 427.4504 |
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| SMILES | CC(C)C[C@H](NC(=O)C(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(O)=O)C=O |
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| Structure | 
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