| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent histone deacetylase SIR2 |
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| Ligand | BDBM50146049 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202251 |
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| IC50 | 89000±n/a nM |
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| Citation |  Posakony, J; Hirao, M; Stevens, S; Simon, JA; Bedalov, A Inhibitors of Sir2: evaluation of splitomicin analogues. J Med Chem47:2635-44 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent histone deacetylase SIR2 |
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| Name: | NAD-dependent histone deacetylase SIR2 |
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| Synonyms: | MAR1 | SIR2 | SIR2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63277.80 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_942450 |
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| Residue: | 562 |
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| Sequence: | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
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| BDBM50146049 |
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| n/a |
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| Name | BDBM50146049 |
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| Synonyms: | 3,4,9,10-Tetrahydro-1,12-dioxa-triphenylene-2,11-dione | CHEMBL89791 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12O4 |
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| Mol. Mass. | 268.2641 |
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| SMILES | O=C1CCc2c(O1)c1OC(=O)CCc1c1ccccc21 |
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| Structure | 
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