| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50146089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1303 (CHEMBL616680) |
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| Ki | 17.2±n/a nM |
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| Citation |  Jurczyk, S; Klodzinska, M; Maryniak, E; Zajdel, P; Pawlowski, M; Tatarczynska, E; Klodzinska, A; Chojnacka-Wójcik, E; Bojarski, AJ; Charakchieva-Minol, S; Duszynska, B; Nowak, G; Maciag, D New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation. J Med Chem47:2659-66 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50146089 |
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| n/a |
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| Name | BDBM50146089 |
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| Synonyms: | 1,3-dimethyl-9-{3-[4-(2'-methoxyphenyl)-piperazin-1-yl]-propyl}-2,4-dioxo-1,3,6,7,8,9-hexahydropyrimido[2,1-f]purine | 8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-1,3-dimethyl-5,6,7,8-tetrahydro-1H-1,3,4b,8,9-pentaaza-fluorene-2,4-dione | CHEMBL328292 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33N7O3 |
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| Mol. Mass. | 467.5639 |
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| SMILES | COc1ccccc1N1CCN(CCCN2CCCn3c2nc2n(C)c(=O)n(C)c(=O)c32)CC1 |
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| Structure | 
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