Reaction Details |
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Target | GTPase KRas |
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Ligand | BDBM50242325 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2134552 (CHEMBL4844162) |
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Kd | 18±n/a nM |
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Citation | Buyanova, M; Cai, S; Cooper, J; Rhodes, C; Salim, H; Sahni, A; Upadhyaya, P; Yang, R; Sarkar, A; Li, N; Wang, QE; Pei, D Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor. J Med Chem64:13038-13053 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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GTPase KRas |
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Name: | GTPase KRas |
Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
Type: | PROTEIN |
Mol. Mass.: | 21656.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1476955 |
Residue: | 189 |
Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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BDBM50242325 |
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n/a |
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Name | BDBM50242325 |
Synonyms: | CHEMBL4072295 |
Type | Small organic molecule |
Emp. Form. | C108H182N44O25S2 |
Mol. Mass. | 2561.01 |
SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CO)NC1=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O |r| |
Structure |
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