| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas |
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| Ligand | BDBM50579094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2134561 (CHEMBL4844171) |
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| Kd | 140±n/a nM |
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| Citation |  Buyanova, M; Cai, S; Cooper, J; Rhodes, C; Salim, H; Sahni, A; Upadhyaya, P; Yang, R; Sarkar, A; Li, N; Wang, QE; Pei, D Discovery of a Bicyclic Peptidyl Pan-Ras Inhibitor. J Med Chem64:13038-13053 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GTPase KRas |
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| Name: | GTPase KRas |
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| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras |
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| Type: | PROTEIN |
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| Mol. Mass.: | 21656.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476955 |
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| Residue: | 189 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM
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| BDBM50579094 |
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| n/a |
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| Name | BDBM50579094 |
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| Synonyms: | CHEMBL4867496 |
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| Type | Small organic molecule |
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| Emp. Form. | C96H123N25O19 |
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| Mol. Mass. | 1931.1599 |
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| SMILES | C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCNC(=O)c3cc(cc(c3)C(=O)N[C@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](c3ccccc3)C(=O)N2)C(=O)NC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)NCCC(=O)NCCC(=O)NC(CCCCN)C(N)=O |r| |
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| Structure | 
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