| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 5 |
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| Ligand | BDBM50123521 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_214965 |
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| IC50 | 200±n/a nM |
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| Citation |  Peukert, S; Brendel, J; Pirard, B; Strübing, C; Kleemann, HW; Böhme, T; Hemmerle, H Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel. Bioorg Med Chem Lett14:2823-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 5 |
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| Name: | Potassium voltage-gated channel subfamily A member 5 |
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| Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 67222.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22460 |
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| Residue: | 613 |
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| Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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| BDBM50123521 |
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| n/a |
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| Name | BDBM50123521 |
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| Synonyms: | CHEMBL317791 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)-biphenyl-2-ylmethyl]-carbamic acid (S)-1-phenyl-ethyl ester | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)-biphenyl-2-ylmethyl]-carbamic acid 1-phenyl-ethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29N3O3 |
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| Mol. Mass. | 479.5696 |
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| SMILES | C[C@H](OC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1 |
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| Structure | 
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