| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50146536 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208709 |
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| IC50 | 1000±n/a nM |
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| Citation |  Haginoya, N; Kobayashi, S; Komoriya, S; Hirokawa, Y; Furugori, T; Nagahara, T Orally active factor Xa inhibitors: 4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine derivatives. Bioorg Med Chem Lett14:2935-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50146536 |
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| n/a |
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| Name | BDBM50146536 |
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| Synonyms: | 4-(6-Chloro-naphthalene-2-sulfonyl)-1-(5-methyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-carbonyl)-piperazine-2-carboxylic acid amide | CHEMBL100751 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN5O4S2 |
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| Mol. Mass. | 534.051 |
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| SMILES | CN1CCc2nc(sc2C1)C(=O)N1CCN(CC1C(N)=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 |
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| Structure | 
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