| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 8 |
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| Ligand | BDBM50579915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2145811 (CHEMBL5030091) |
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| IC50 | 4.5±n/a nM |
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| Citation |  Saito, K; Shinozuka, T; Nakao, A; Kunikata, T; Nakai, D; Nagai, Y; Naito, S Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent. Bioorg Med Chem Lett54:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 8 |
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| Name: | Cyclin-dependent kinase 8 |
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| Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 53300.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49336 |
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| Residue: | 464 |
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| Sequence: | MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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| BDBM50579915 |
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| n/a |
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| Name | BDBM50579915 |
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| Synonyms: | CHEMBL4442570 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23FN4O3S |
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| Mol. Mass. | 430.496 |
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| SMILES | CN(C)C(=O)CCCc1ccc(Oc2cc(C)nc3sc(C(N)=O)c(N)c23)c(F)c1 |
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| Structure | 
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