| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50148053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195086 (CHEMBL797540) |
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| IC50 | 1100±n/a nM |
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| Citation |  Greenbaum, DC; Mackey, Z; Hansell, E; Doyle, P; Gut, J; Caffrey, CR; Lehrman, J; Rosenthal, PJ; McKerrow, JH; Chibale, K Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem47:3212-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50148053 |
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| n/a |
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| Name | BDBM50148053 |
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| Synonyms: | (1E)-1-(1,1'-biphenyl-3-yl)ethan-1-one thiosemicarbazone | CHEMBL108035 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N3S |
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| Mol. Mass. | 269.365 |
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| SMILES | CC(=NNC(N)=S)c1cccc(c1)-c1ccccc1 |w:2.2| |
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| Structure | 
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