| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
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| Ligand | BDBM50580221 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2147579 (CHEMBL5031925) |
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| IC50 | 7.7±n/a nM |
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| Citation |  Kai, H; Horiguchi, T; Kameyma, T; Onodera, N; Itoh, N; Fujii, Y; Ichihashi, Y; Hirai, K; Shintani, T; Nakamura, K; Minami, K; Kasai, E; Yoneda, S; Murakami, Y; Ogawa, H; Sekimoto, R; Shinohara, S; Yoshida, O; Kurose, N Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists. Bioorg Med Chem Lett52:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 3 |
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| Name: | P2X purinoceptor 3 |
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| Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44397.63 |
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| Organism: | RAT |
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| Description: | Purinergic, P2X3 0 RAT::P49654 |
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| Residue: | 397 |
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| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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| BDBM50580221 |
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| n/a |
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| Name | BDBM50580221 |
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| Synonyms: | CHEMBL5073093 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20ClN5O5S |
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| Mol. Mass. | 513.953 |
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| SMILES | C[C@@H](Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ccsn3)cc2)n(Cc2ccc(Cl)cc2)c1=O)C(O)=O |r| |
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| Structure | 
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