| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte growth factor activator |
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| Ligand | BDBM50580344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2148119 (CHEMBL5032465) |
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| IC50 | 3173±n/a nM |
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| Citation |  Damalanka, VC; Voss, JJLP; Mahoney, MW; Primeau, T; Li, S; Klampfer, L; Janetka, JW Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression. J Med Chem64:18158-18174 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatocyte growth factor activator |
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| Name: | Hepatocyte growth factor activator |
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| Synonyms: | HGF activator | HGFA | HGFAC | HGFA_HUMAN | Hepatocyte growth factor activator | Hepatocyte growth factor activator long chain | Hepatocyte growth factor activator short chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70690.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109514 |
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| Residue: | 655 |
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| Sequence: | MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILV
TSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLH
ACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQD
PQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGT
RHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST
SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE
YCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHP
WLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIE
KYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGW
GHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGG
PLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
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| BDBM50580344 |
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| n/a |
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| Name | BDBM50580344 |
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| Synonyms: | CHEMBL5075134 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H43N9O6S |
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| Mol. Mass. | 705.827 |
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| SMILES | CC(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
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| Structure | 
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