| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 2 group E member 1 |
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| Ligand | BDBM14777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2148634 (CHEMBL5033032) |
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| EC50 | 5000±n/a nM |
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| Citation |  Faudone, G; Bischoff-Kont, I; Rachor, L; Willems, S; Zhubi, R; Kaiser, A; Chaikuad, A; Knapp, S; Fürst, R; Heering, J; Merk, D Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. J Med Chem64:8727-8738 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 2 group E member 1 |
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| Name: | Nuclear receptor subfamily 2 group E member 1 |
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| Synonyms: | NR2E1 | NR2E1_HUMAN | Nuclear receptor TLX | Protein tailless homolog | TLX | Tll | hTll |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42606.25 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_104473 |
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| Residue: | 385 |
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| Sequence: | MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGC
PVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHF
PSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEV
ATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDAN
TLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTH
SGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEE
VFFKKTIGNVPITRLLSDMYKSSDI
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| BDBM14777 |
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| n/a |
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| Name | BDBM14777 |
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| Synonyms: | (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione | CHEMBL779 | Cialis | GF 196960 | Tadalafil |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N3O4 |
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| Mol. Mass. | 389.404 |
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| SMILES | [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r| |
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| Structure | 
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