Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMelanocortin receptor 4
LigandBDBM50148978
Substrate/Competitorn/a
Meas. Tech.ChEBML_106507
Ki 320±n/a nM
Citation Marsilje THRoses JBCalderwood EFStroud SGForsyth NEBlackburn CYowe DLMiao WDrabic SVBohane MDScott Daniels JLi PWu LPatane MAClaiborne CF Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorg Med Chem Lett 14:3721-5 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50148978
n/a
NameBDBM50148978
Synonyms:2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-phenyl}-5-ethyl-1-methyl-1H-imidazole | CHEMBL332584
TypeSmall organic molecule
Emp. Form.C21H23BrN2O
Mol. Mass.399.324
SMILESCCc1cnc(-c2ccccc2CCc2cc(Br)ccc2OC)n1C
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: