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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Ligand | BDBM50149143 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_143096 (CHEMBL749346) | ||
| IC50 | 23.0±n/a nM | ||
| Citation |  Tatsumi, R; Seio, K; Fujio, M; Katayama, J; Horikawa, T; Hashimoto, K; Tanaka, H (+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett14:3781-4 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-7 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56502.44 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q05941 | ||
| Residue: | 502 | ||
| Sequence: |
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| BDBM50149143 | |||
| n/a | |||
| Name | BDBM50149143 | ||
| Synonyms: | 3-(2-Benzo[b]thiophen-2-yl-ethyl)-1-aza-bicyclo[2.2.2]octane | CHEMBL330789 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H21NS | ||
| Mol. Mass. | 271.42 | ||
| SMILES | C(Cc1cc2ccccc2s1)C1CN2CCC1CC2 |(-1.35,1.7,;-.02,.93,;1.31,1.7,;2.75,1.14,;3.72,2.33,;5.26,2.4,;5.96,3.77,;5.12,5.08,;3.58,4.99,;2.88,3.63,;1.38,3.24,;-2.68,.93,;-2.68,-.61,;-4.01,-1.36,;-5.34,-.61,;-5.34,.93,;-4.01,1.72,;-4.64,.55,;-3.59,-.17,)| | ||
| Structure | 
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