| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50149199 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_43656 |
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| IC50 | 147±n/a nM |
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| Citation |  Auvin, S; Pignol, B; Navet, E; Pons, D; Marin, JG; Bigg, D; Chabrier, PE Novel dual inhibitors of calpain and lipid peroxidation. Bioorg Med Chem Lett14:3825-8 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50149199 |
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| n/a |
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| Name | BDBM50149199 |
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| Synonyms: | 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid [(S)-1-((S)-2-hydroxy-tetrahydro-furan-3-ylcarbamoyl)-3-methyl-butyl]-amide | CHEMBL123621 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H36N2O6 |
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| Mol. Mass. | 448.5524 |
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| SMILES | CC(C)C[C@H](NC(=O)C1(C)CCc2c(C)c(O)c(C)c(C)c2O1)C(=O)N[C@H]1CCOC1O |
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| Structure | 
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