| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50149277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155618 (CHEMBL766353) |
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| IC50 | 21000±n/a nM |
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| Citation |  Elokdah, H; Abou-Gharbia, M; Hennan, JK; McFarlane, G; Mugford, CP; Krishnamurthy, G; Crandall, DL Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem47:3491-4 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50149277 |
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| n/a |
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| Name | BDBM50149277 |
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| Synonyms: | CHEMBL117359 | [1-(4-tert-Butyl-benzyl)-5-(3-methoxy-phenyl)-1H-indol-3-yl]-oxo-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27NO4 |
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| Mol. Mass. | 441.5183 |
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| SMILES | COc1cccc(c1)-c1ccc2n(Cc3ccc(cc3)C(C)(C)C)cc(C(=O)C(O)=O)c2c1 |
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| Structure | 
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