| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50581342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2150526 (CHEMBL5034988) |
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| Ki | 490±n/a nM |
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| Citation |  Li, Y; Fan, W; Gong, Q; Tian, J; Zhou, M; Li, Q; Uwituze, LB; Zhang, Z; Hong, R; Wang, R Structure-Based Optimization of 3-Phenyl- J Med Chem64:10260-10285 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50581342 |
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| n/a |
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| Name | BDBM50581342 |
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| Synonyms: | CHEMBL5077322 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23F6N3O6S2 |
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| Mol. Mass. | 675.619 |
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| SMILES | Cc1ccc(-c2ccsc2S(=O)(=O)NCCNC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(Oc2ccc(O)c(O)c2)c1 |
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| Structure | 
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