| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NT-3 growth factor receptor |
|---|
| Ligand | BDBM50581356 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2150721 (CHEMBL5035183) |
|---|
| IC50 | 0.200000±n/a nM |
|---|
| Citation |  Liu, Z; Yu, P; Dong, L; Wang, W; Duan, S; Wang, B; Gong, X; Ye, L; Wang, H; Tian, J Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer. J Med Chem64:10286-10296 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NT-3 growth factor receptor |
|---|
| Name: | NT-3 growth factor receptor |
|---|
| Synonyms: | GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 94428.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16288 |
|---|
| Residue: | 839 |
|---|
| Sequence: | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
|
|
|
|---|
| BDBM50581356 |
|---|
| n/a |
|---|
| Name | BDBM50581356 |
|---|
| Synonyms: | CHEMBL5080010 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19FN6O3 |
|---|
| Mol. Mass. | 410.4017 |
|---|
| SMILES | Fc1cnc2OCC3(CC3)NC(=O)c3cnn4ccc(nc34)N3CCOC[C@@H]3c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
