Reaction Details |
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Target | Kappa-type opioid receptor |
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Ligand | BDBM21130 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2150929 (CHEMBL5035391) |
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EC50 | 12±n/a nM |
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Citation | Zhang, M; Xu, B; Li, N; Zhang, R; Zhang, Q; Shi, X; Xu, K; Xiao, J; Chen, D; Niu, J; Shi, Y; Fang, Q Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. J Med Chem64:13394-13409 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kappa-type opioid receptor |
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Name: | Kappa-type opioid receptor |
Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 42648.76 |
Organism: | Homo sapiens (Human) |
Description: | P41145 |
Residue: | 380 |
Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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BDBM21130 |
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n/a |
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Name | BDBM21130 |
Synonyms: | N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide | N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide | U-69593 | U69,593 | [3H]U69593 |
Type | radiolabeled ligand |
Emp. Form. | C22H32N2O2 |
Mol. Mass. | 356.5017 |
SMILES | CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1 |
Structure |
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