Ki Summary

Reaction Details

Report a problem with these data

Target

Neuropeptide FF receptor 2

Ligand

BDBM50581385

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2150935 (CHEMBL5035397)

EC50

112±n/a nM

Citation

Zhang, M; Xu, B; Li, N; Zhang, R; Zhang, Q; Shi, X; Xu, K; Xiao, J; Chen, D; Niu, J; Shi, Y; Fang, Q Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. J Med Chem64:13394-13409 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neuropeptide FF receptor 2

Name:

Neuropeptide FF receptor 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

60293.78

Organism:

Homo sapiens (Human)

Description:

NPFF2 0 HUMAN::Q9Y5X5

Residue:

522

Sequence:

MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRR
LGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWN
VNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHT
VTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVA
IAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQN
KTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKN
QEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFA
HWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQ
LVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI

BDBM50581385

n/a

Name

BDBM50581385

Synonyms:

CHEMBL5086601

Type

Small organic molecule

Emp. Form.

C56H77N15O12

Mol. Mass.

1152.3039

SMILES

CN1[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r|

Structure