Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 1 |
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Ligand | BDBM50149864 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305548 (CHEMBL828567) |
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IC50 | 3600±n/a nM |
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Citation | Smith, G; Ruhland, T; Mikkelsen, G; Andersen, K; Christoffersen, CT; Alifrangis, LH; Mørk, A; Wren, SP; Harris, N; Wyman, BM; Brandt, G The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors. Bioorg Med Chem Lett14:4027-30 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 1 |
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Name: | Sodium- and chloride-dependent glycine transporter 1 |
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
Type: | Enzyme |
Mol. Mass.: | 78270.54 |
Organism: | Homo sapiens (Human) |
Description: | P48067 |
Residue: | 706 |
Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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BDBM50149864 |
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n/a |
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Name | BDBM50149864 |
Synonyms: | CHEMBL181698 | {4-[2-(4-Hydroxy-phenylsulfanyl)-phenyl]-2,5-dimethyl-piperazin-1-yl}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C20H24N2O3S |
Mol. Mass. | 372.481 |
SMILES | CC1CN(C(C)CN1CC(O)=O)c1ccccc1Sc1ccc(O)cc1 |
Structure |
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