Ki Summary

Reaction Details

Report a problem with these data

Target

5-hydroxytryptamine receptor 6

Ligand

BDBM50150673

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_305399 (CHEMBL833049)

IC50

>1000±n/a nM

Citation

Holmberg, P; Sohn, D; Leideborg, R; Caldirola, P; Zlatoidsky, P; Hanson, S; Mohell, N; Rosqvist, S; Nordvall, G; Johansson, AM; Johansson, R Novel 2-aminotetralin and 3-aminochroman derivatives as selective serotonin 5-HT7 receptor agonists and antagonists. J Med Chem47:3927-30 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 6

Name:

5-hydroxytryptamine receptor 6

Synonyms:

5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5HT6R_RAT | Htr6 | ST-B17 | Serotonin (5-HT) receptor | Serotonin 6 (5-HT6) receptor | Serotonin receptor 6

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46945.51

Organism:

RAT

Description:

5-HT6 HTR6 RAT::P31388

Residue:

436

Sequence:

MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQC
RLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVP
RTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVP
DQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLS
QTLWSLRYGRIHSVPP

BDBM50150673

n/a

Name

BDBM50150673

Synonyms:

CHEMBL363466 | [(S)-5-(2,6-Dimethoxy-phenyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-dimethyl-amine

Type

Small organic molecule

Emp. Form.

C20H25NO2

Mol. Mass.

311.418

SMILES

COc1cccc(OC)c1-c1cccc2C[C@H](CCc12)N(C)C |wD:16.22,(2.58,2.38,;1.26,1.59,;-.09,2.35,;-.11,3.87,;-1.44,4.65,;-2.77,3.85,;-2.75,2.31,;-4.09,1.52,;-4.07,-.02,;-1.42,1.56,;-1.42,.02,;-2.73,-.76,;-2.73,-2.3,;-1.42,-3.07,;-.09,-2.3,;1.25,-3.07,;2.58,-2.32,;2.58,-.78,;1.25,.02,;-.09,-.76,;4.08,-2.72,;4.29,-4.24,;5.24,-1.69,)|

Structure