| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 |
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| Ligand | BDBM50582532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2154907 (CHEMBL5039567) |
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| IC50 | 1100±n/a nM |
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| Citation |  Tilekar, K; Hess, JD; Upadhyay, N; Bianco, AL; Schweipert, M; Laghezza, A; Loiodice, F; Meyer-Almes, FJ; Aguilera, RJ; Lavecchia, A; C S, R Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their J Med Chem64:6949-6971 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 |
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| Name: | Histone deacetylase 4 |
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| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119049.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56524 |
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| Residue: | 1084 |
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| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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| BDBM50582532 |
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| n/a |
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| Name | BDBM50582532 |
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| Synonyms: | CHEMBL5085545 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H13BrF2N2O4S |
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| Mol. Mass. | 519.315 |
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| SMILES | Fc1cc(F)c(NC(=O)COc2ccc3cc(\C=C4\SC(=O)NC4=O)ccc3c2)c(Br)c1 |
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| Structure | 
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